姓名:陈玉洁 | 性别:女 |
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学历:博士研究生 | 学位:理学博士 | |
职称:讲师 | 政治面貌：群众 | |
办公电话: | Email: chenyujie@shiep.edu.cn | |
系别：物理系 | 办公室:临港B2楼A204室 | |
个人简介: 陈玉洁于2024年9月就任上海电力大学数理学院讲师，主要研究方向为生物物理与计算化学交叉领域。陈玉洁2021年毕业于复旦大学，获得凝聚态物理专业理学博士学位，2021至2024年于复旦大学物理学系从事博士后研究。陈玉洁在相关研究领域共发表了19篇SCI论文，其中以第一/共一/通讯作者的身份在Small、Nanoscale、ACS Chemical Neuroscience等期刊发表8篇成果，包括2篇封面文章和1篇热点论文。 | ||
研究方向:主要从事神经退行性疾病相关蛋白的计算物理研究，包括1）阿尔茨海默症相关Aβ/tau蛋白的构象动力学；2）小分子抑制剂与Aβ/tau蛋白的相互作用机制；3）ALS相关突变对TDP-43/hnRNPA2蛋白的构象调控等。 | ||
主讲课程:《大学物理B》、《大学物理实验》 | ||
科研论文: [1]Yujie Chen#; Xun Sun#; Yiming Tang; Yuan Tan; Cong Guo; Tong Pan; Xuefeng Zhang; Jinghui Luo; Guanghong Wei; Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule‐Binding Domain and Enhances Liquid‐Liquid Phase Separation of Tau, Small, 2406429,1-12(2024). [2]Yujie Chen, Chendi Zhan, Xuhua Li, Tong Pan, Yifei Yao, Yuan Tan, Guanghong Wei*, Five similar anthocyanidin molecules display distinct disruptive effects and mechanisms of action on Aβ1-42 protofibril: a molecular dynamic simulation study.International Journal of Biological Macromolecules, 256,128467(2023). [3]Yujie Chen, Xuhua Li, Chendi Zhan, Zenghui Lao, Fangying Li, Xuewei Dong*, Guanghong Wei*. A comprehensive insight into the mechanisms of dopamine in disrupting Aβ protofibrils and inhibiting Aβ aggregation. ACS Chemical Neuroscience, 12, 4007(2021). [3]Yujie Chen, Guanghong Wei*, Jun Zhao, Ruth Nussinov, and Buyong Ma*. Computational investigation of gantenerumab and crenezumab’s recognition of Aβ fibrils in Alzheimer's disease brain tissue. ACS Chemical Neuroscience, 11, 3233(2020). [4]Yujie Chen, Zihan Chen, Yunxiang Sun, Jiangtao Lei and Guanghong Wei*. Mechanistic Insights into the Inhibition and Size effects of Graphene Oxide Nanosheets on the Aggregation of an Amyloid-β Peptide Fragment. Nanoscale, 10, 8989(2018). [5]Fangying Li#, Yujie Chen#, Yiming Tang, Xianshi Liu, and Guanghong Wei*. Dissecting the effect of ALS mutation G335D on the early aggregation of the TDP-43 amyloidogenic core peptide: helix-to-β-sheet transition and conformational shift. Journal of Chemical Information and Modeling, 63, 3579(2023). [6]Tong Pan, Yuan Tan, Xuewei Dong, Yiming Tang, Zhongyuan Yang, Yujie Chen*, Guanghong Wei*; Elucidating How Terminal Capping of Tau Hexapeptide PHF6 Modulates the Interactions between PHF6 Fibrils and Membranes. Journal of Physical Chemistry B, 129, 5449(2025). [7]Yuan Tan, Yujie Chen*, Xianshi Liu, Yiming Tang, Zenghui Lao, and Guanghong Wei*. Dissecting how ALS-associated D290V mutation enhances pathogenic aggregation of hnRNPA2(286-291) peptides: dynamics and conformational ensembles. International Journal of Biological Macromolecules, 241, 124659(2023). [8]Fangying Li, Yujie Chen*, Xianshi Liu, Yiming Tang, Xuewei Dong, Guanghong Wei*. Atomistic insights into A315E mutation-enhanced pathogenicity of TDP-43 core fibrils. ACS Chemical Neuroscience, 13, 2743(2022). | ||
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